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The clEDS type 1 is generally distinguishable from cEDS for the absence of atrophic scarring [28, 45, 53,54,55,56,57], whereas a more severe multisystemic presentation in clEDS type 2 should assist the differential diagnosis with cEDS [43, 52, 58,59,60]

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Three e-cigarette devices were used for these experiments: 2 that used a tank system that is directly filled with e-liquid and one that used a cartridge with a cotton fiber on which to drip the liquid